In-vitro cellular uptake and transport study of 9-nitrocamptothecin PLGA nanoparticles across Caco-2 cell monolayer model

in-vitro cellular uptake and transport study of 9-nitrocamptothecin plga nanoparticles across caco-2 cell monolayer model

the uptake and transport of 9-nitrocamptothecin (9-nc), a potent anticancer agent, across caco-2 cell monolayers was studied as a free and plga nanoparticle loaded drug. different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. the transport of nanoparticles across the caco-2 cell monolayer as a func...

In-vitro Cellular Uptake and Transport Study of 9-Nitrocamptothecin PLGA Nanoparticles Across Caco-2 Cell Monolayer Model

The uptake and transport of 9-nitrocamptothecin (9-NC), a potent anticancer agent, across Caco-2 cell monolayers was studied as a free and PLGA nanoparticle loaded drug. Different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. The transport of nanoparticles across the Caco-2 cell monolayer as a func...

Transport Across Caco-2 Monolayer: Biological, Pharmaceutical and Analytical Considerations

study of the copolymer structure effect on physicochemical characteristics and in vitro stability of plga–peg nanoparticles loaded 9-nitrocamptothecin

9-nitrocamptothecin (9-nc) is a semisynthetic and a low soluble analogue of camptothecin alkaloids that target nuclear enzyme topoisomerase i. the unstable lactone form of 9-nc in biological fluids requires for its cytotoxic activity. to improve aqueous solubility and stability in biological media, 9-nc was loaded in polymeric nanoparticles. in this paper, we studied the effect of peg percent (...

Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin.

Biodegradable nanoparticles containing salmon calcitonin (sCT) were formulated using protein-fatty acid complexes, and their in vitro transport against a Caco-2 cell monolayer and the extent of in vivo oral uptake were assessed. Positively charged sCT was hydrophobically ion paired to form physical complexes with fatty acid, phospholipid, and surfactant. Among the complexes, sodium oleate was u...